郭 昌


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姓  名:

郭 昌

地  址:

合肥微尺度物质科学国家研究中心

中国科学技术大学

邮  编:

230026

电  话:

15155932590

邮  箱:




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 教育与科研经历

2018.03 - 至今

特任教授,博士生导师,合肥微尺度物质科学国家研究中心

2017.02-2018.02

特任研究员,中国科学技术大学,合肥微尺度物质科学国家研究中心

2013.08-2017.01

博士后,德国明斯特大学

2007.09-2013.06

博士,中国科学技术大学

2003.08-2007.06

学士,中国科学技术大学


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 目前研究方向

  研究方向:电化学合成,不对称催化
  研究工作包括不对称电化学反应、联合催化、天然产物全合成。以新型不对称催化研究为基础提高反应活性与选择性,并将这些方法学用于天然产物的合成,发展高效、原子经济性和环境友好的现代有机合成化学


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 代表性论文

1.

xu, x.; wang, m.; peng, l.; guo, c.* nickel-catalyzed asymmetric propargylation for the synthesis of axially chiral 1,3-disubstituted allenes. j. am. chem. soc. 2022, 144, 21022―21029.

2.

zhang, j.; chang, x.; xu, x.; wang, h.; peng, l.; guo, c.* nickel-catalyzed switchable 1,3-dienylation and enantioselective allenylation of phosphine oxides. nat. commun. 2022, 13, 7049.

3.

liang, k.; zhang, q.; guo, c.* nickel-catalyzed switchable asymmetric electrochemical functionalization of alkenes. sci. adv. 2022, 8, eadd7134.

4.

zhang, q.; liang, k.; guo, c.* enantioselective nickel-catalyzed electrochemical radical allylation. d. angew. chem. int. ed. 2022, 61, e202210632.

5.

he, z.; peng, l.; guo, c.* catalytic stereodivergent total synthesis of amathaspiramide d. nat. synth. 2022, 1, 393-400.

6.

hu, q.; he, z.; peng, l.; guo, c.* combining nickel and squaramide catalysis for the stereodivergent α-propargylation of oxindoles. nat. synth. 2022, 1, 322-331.

7.

xu, x.; peng, l.; chang, x.; guo, c.* ni/chiral sodium carboxylate dual catalyzed asymmetric o-propargylation. j. am. chem. soc. 2021, 143, 21048-21055.

8.

peng, l.; wang, h.; guo, c.* copper-catalyzed enantioselective difluoromethylation of amino acids via difluorocarbene. j. am. chem. soc. 2021, 143, 6376―6381.

9.

chang, x.; zhang, j.; peng, l.; guo, c.* collective synthesis of acetylenic pharmaceuticals via enantioselective nickel/lewis acid-catalyzed propargylic alkylation. nat. commum. 2021, 12, 299.

10.

zhang, q.; liang, k.; guo, c.* asymmetric electrochemical arylation in the formal synthesis of ( )-amurensinine. ccs chem. 2021, 3, 338.

11.

chang, x.; zhang, j.; zhang, q.; guo, c.* merging electrosynthesis and bifunctional squaramide catalysis in the asymmetric detrifluoroacetylative alkylation reactions. angew. chem. int. ed. 2020, 59, 18500―18504.

12.

peng, l.; he, z.; xu, x.; guo, c.* cooperative ni/cu-catalyzed asymmetric propargylic alkylation of aldimine esters. angew. chem. int. ed. 2020, 59, 14270―14274.

13.

chang, x.; zhang, q.; guo, c.* asymmetric electrochemical transformation. angew. chem. int. ed. 2020, 59, 12612―12622.

14.

wang, h.; hu, q.; wang, m.; guo, c.* enantioselective [4 2] annulation to the concise synthesis of chiral dihydrocarbazoles. iscience 2020, 23, 100840.

15.

zhang, q.; chang, x.; peng, l.; guo, c.* asymmetric lewis acid catalyzed electrochemical alkylation. angew. chem. int. ed. 2019, 58, 6999―7003.

16.

chang, x.; zhang, q.; guo, c.* switchable smiles rearrangement for enantioselective o-aryl amination. org. lett. 2019, 21, 4915―4918.

17.

wang, h.; guo, c.* enantioselective γ‐addition of pyrazole and imidazole heterocycles to allenoates catalyzed by chiral phosphine. angew. chem. int. ed. 2019, 58, 2854―2858.

18.

chang, x.; zhang, q.; guo. c.* electrochemical reductive smiles rearrangement for c−n bond formation. org. lett. 2019, 21, 10―13.

19.

guo, c.*; janssen-müller, d.; fleige, m.; lerchen, a.; daniliuc, c. g.; glorius, f.*mechanistic studies on a cooperative nhc organocatalysis/palladium catalysis system: uncovering significant lessons for mixed chiral pd(nhc)(pr3) catalyst design. j. am. chem. soc. 2017, 139, 4443―4451.

20.

guo, c.; fleige, m.; janssen-müller, d.; daniliuc, c. g.; glorius, f.* cooperative n-heterocyclic carbene/palladium-catalyzed enantioselective umpolung annulations, j. am. chem. soc. 2016, 138, 7840―7843.

21.

guo, c.; fleige, m.; janssen-müller, d.; daniliuc, c. g.; glorius, f. * switchable selectivity in an nhc-catalysed dearomatizing annulation reaction, nat. chem. 2015, 7, 842―847.

22.

guo,c.; sahoo, b.; daniliuc, c. g.; glorius, f.*n-heterocyclic carbene catalyzed switchable reactions of enals with azoalkenes: formal [4 3] and [4 1] annulations for the synthesis of 1,2-diazepines and pyrazoles, j. am. chem. soc. 2014, 136, 17402―17405.

23.

guo, c.; schedler, m.; daniliuc, c. g.; glorius,f.*n-heterocyclic carbene catalyzed formal [3 2] annulation reaction of enals: an efficient enantioselective access to spiro-heterocycles, angew. chem. int. ed. 2014, 53, 10232―10236.

24.

guo. c.; song, j.; gong, l.-z. biomimetic asymmetric 1,3-dioplar cycloaddition: amino acid precursors in biosynthesis serve as latent azomethine ylides. org. lett. 2013, 11, 2676―2679.

25.

guo, c.; song, j.; huang, j.-z.; chen, p.-h.; luo, s.-w.; gong, l.-z. * core-structure-oriented asymmetric organocatalytic substitution of 3-hydroxyoxindoles: application in the enantioselective total synthesis of ( )-folicanthine. angew. chem. int. ed. 2012, 51, 1046―1050.

26.

guo, c.; song, j.; luo, s.-w.; gong, l.-z. * enantioselective oxidative cross-coupling reaction of 3-indolylmethyl c-h bonds with 1,3-dicarbonyls using a chiral lewis acid-bonded nucleophile to control stereochemistry. angew. chem. int. ed. 2010, 49, 5558―5562.

27.

guo, c.; xue, m.-x.; zhu, m.-k.; gong, l.-z.* organocatalytic asymmetric formal [3 2] cycloaddition reaction of isocyanoesters to nitroolefins leading to highly optically active dihydropyrroles. angew. chem. int. ed. 2008, 47, 3414―3417.


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